Mazza was born in Rosario, Santa Fe Province, and was raised in Paraná, Entre Ríos Province.
Considered as the first Latin American supermodel, Mazza rose to prominence in the 1990s and became a household name after appearing in the cover of the Sports Illustrated Swimsuit Issue of 1996 alongside Tyra Banks.
A model since age 14, Mazza has also worked as an actress, presenter and brand ambassador.
As a businesswoman, she has released three perfumes, her own magazine, and created an eyewear company and production company.
Mazza remains a leading figure in Latin American fashion, and is considered the most important fashion model in Argentine history.